CARDIOMYOCYTE OGA HAPLOINSUFFICIENCY INCREASES O-GLCNACYLATION BUT HASTENS VENTRICULAR DYSFUNCTION FOLLOWING MYOCARDIAL INFARCTION.

Cardiomyocyte Oga haploinsufficiency increases O-GlcNAcylation but hastens ventricular dysfunction following myocardial infarction.

RationaleThe beta-O-linkage of N-acetylglucosamine (i.e., O-GlcNAc) to proteins is a pro-adaptive response to cellular insults.To this end, increased protein O-GlcNAcylation improves short-term survival of cardiomyocytes subjected to acute injury.This observation has been repeated by multiple groups and in multiple models; however, whether increase

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A novel in vitro model to study prolonged Pseudomonas aeruginosa infection in the cystic fibrosis bronchial epithelium.

Pseudomonas aeruginosa (PA) is known to chronically infect airways of people with cystic fibrosis (CF) by early adulthood.PA infections can lead to increased airway inflammation and lung tissue damage, ultimately contributing to decreased lung function and quality of life.Existing models of PA infection in vitro commonly utilize 1-6-hour time cours

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Enhancing Unmanned Aerial Vehicle Task Assignment with the Adaptive Sampling-Based Task Rationality Review Algorithm

As the application areas of unmanned aerial vehicles (UAVs) continue to expand, the importance of UAV task allocation becomes increasingly evident.A highly effective and efficient UAV task assignment method can significantly enhance the quality of task completion.However, traditional heuristic algorithms often perform SAFFRON 2020 poorly in complex

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Analysis of inter-country input-output table based on citation network: How to measure the competition and collaboration between industrial sectors on the global value chain.

The input-output table is comprehensive and detailed in describing the national economic system with complex economic relationships, which embodies information of supply SAFFRON 2020 and demand among industrial sectors.This paper aims to scale the degree of competition/collaboration on the global value chain from the perspective of econophysics.Glo

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